The 2005 & 2008 Launch and Recovery Conferences were outstanding successes drawing upon the leading experts from around the world to discuss emergent technical issues. The 2010 Launch and Recovery Conference of Manned and Unmanned Vehicles from Marine Platforms represents a unique opportunity to also include the vehicles themselves in the discussion and the special interfaces that must exist between the vehicle and the platform. New participants and those who attended the previous conferences are encouraged to present their current cutting edge technology, and discuss progress that has occurred over the intervening two years. Unmanned vehicles are increasingly integrated into the day-to-day operations of naval and commercial maritime operations, from ocean platform inspection, to search-and-rescue, to surface and antisubmarine warfare. At the same time, the use of small manned vehicles is also on the rise, whether high-speed boats on Coast Guard ships or helicopters on research vessels. The need to operate both manned and unmanned vehicles from the same platform is of increasing importance, and so are the means to quickly and safely launch and recover a wide variety of such vehicles - which are evolving at a rapid pace - is an area of intense research and development in national and international naval, commercial and academic sectors.